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folE [2019-05-29 17:07:24]
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folE [2019-05-29 17:07:24]

GTP cyclohydrolase I
locus
BSU22780
pI
6.34
mw
21.07 kDa
protein length
190 aa Sequence Blast
gene length
573 bp Sequence Blast
function
biosynthesis of folate
product
GTP cyclohydrolase IA
essential
yes
ec
3.5.4.16
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    2,384,783 2,385,355

    Phenotypes of a mutant

  • essential [Pubmed|28189581]

    • The protein

    Catalyzed reaction/ biological activity

  • GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

    • Protein family

  • citrate synthase family (according to Swiss-Prot)

    • [SW|Cofactors]

  • zinc-dependent enzyme [Pubmed|19767425]

    • Structure

  • [PDB|3D2O] (enzyme from ''Neisseria gonorrhoeae'') [Pubmed|17032654]

    • Expression and Regulation

    Operons

    genes
    [gene|7732A37D59E2643F232F2C0AFE51BCF7A79EDE29|folE]-[gene|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]
    description
    [Pubmed|2123343]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|2123343], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulation

  • constitutive [Pubmed|19767425]
    • view in new tab

    References

  • 1551827,2123343,17032654,19767425,28189581